Usually, in memes "tweaking (https://saferloop.com/tweaking-meaning-in-slang/)" is done with exaggerated facial expressions, funny miscommunications, or unexpected situations. In the case of an irrational or an outlandish claim, users may place a caption on the meme that says "Bro is tweaking." The saying has become popular as it's brief, descriptive and can be used in a lot of humorous situations. On apps such as TikTok and Instagram Reels, it's used to describe dramatic reactions, weird opinions, and situations that warrant unnecessary panic.
Source: Saferloop (https://saferloop.com/)